Virtual Metabolic Human

The Virtual Metabolic Human (VMH) is a resource that can explicitly link the human metabolism, gut microbiome metabolism, nutrition, and disease. VMH integrates and maintains relations between these entities:

Considering the increasing complexity of metabolic networks, tools that enable to interactively visualize metabolic network content and integrate omics data and simulation results are highly desirable. ReconMap (Noronha et al., 2016, PMID 27993782) is a manually drawn comprehensive map, consistent with the content of Recon2, and is available through a web interface that allows content query, visualization of custom datasets and submission of feedback to manual curators. An extention of the Constraint-Based Reconstruction and Analysis (COBRA) toolbox (Schellenberger et al., 2011, PMID 21886097) was developed to interact with ReconMap and allows users to directly upload simulation results to ReconMap.

VMH and ReconMap can be connected to disease-specific maps, such as the Parkinson’s disease map, thereby enabling investigations beyond metabolic pathways.

Ines Thiele Ines Thiele, PhD
University of Luxembourg, Luxembourg
Head of the Molecular Systems Physiology Group, Luxembourg Centre for Systems Biomedicine; the Leader of the Virtual Metabolic Human project;
the Leader of the Recon2 project
Ronan Fleming Ronan Fleming, PhD
University of Luxembourg, Luxembourg
Senior Scientist, Luxembourg Centre for Systems Biomedicine;
the Leader of the ReconMap project