In each case, a disease map is designed while taking into account the goals and objectives of a particular project,
specifics of disease conditions and disease subtypes. Here we propose a set of guidelines for a disease map construction
and define some concepts that are derived from our collective experience and that might be helpful for developing a new disease map.
- Form a panel of domain experts: leading researchers, clinicians and biologist, with experience in the field of this particular disorder.
- Define the scope of a disease map. What are the disease hallmarks? What are the key modules? What levels of granularity should be included?
- Develop an overview map and start determining the content in close communication with the domain experts.
- Develop a draft version reusing information from other disease maps and pathway databases.
- Develop a comprehensive version.
These steps can be done in parallel.
- 6 months: Steps 1-3 are progressed simultaneously. An overview diagram is developed and improved.
The results are used for drafting the first publication on the resource.
A logical model can be developed for this high-level view.
- 18 months: The first version of a map is developed.
Pathway databases and other disease maps are to be used where possible in order to minimise the time necessary for
developing a detailed comprehensive view.
- 36 months: Refined version is complete and made accessible online for browsing, data interpretation
and hypothesis generation, new disease-specific pathway modules are developed from scratch where necessary.