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About

The Disease Maps Project as a large-scale community effort was initiated by the Luxembourg Centre for Systems Biomedicine, the European Institute for Systems Biology and Medicine and the Institut Curie.

Get involved

We are actively expanding the list of diseases covered by the Disease Maps Project and are looking for new contributors interested in molecular mechanisms of diseases: computational biology teams working on disease models and clinicians or experimental biologists who would like to contribute as domain experts. If you are working on one of the diseases which are already listed on this website, please do not be discouraged: we would be happy to collaborate and integrate your work in the overall effort.

Principal Investigators

Charles Auffray, PhD

Research Director at CNRS, Founding Director of the European Institute for Systems Biology and Medicine, Lyon, France

Reinhard Schneider, PhD

Head of Bioinformatics Core, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Luxembourg

Emmanuel Barillot, PhD

Director of the U900 Institut Curie/INSERM/Ecole des Mines ParisTech, Paris, France

Project Leaders

The leaders of the Disease Maps Project develop and refine the concept of disease maps, coordinate the activities of the community effort, help initiating new maps, advise on best practices and offer guidelines.

Alexander Mazein, PhD

Senior Researcher, European Institute for Systems Biology and Medicine, Lyon, France

Marek Ostaszewski, PhD

Researcher, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Luxembourg

Inna Kuperstein, PhD

ACSN Project Coordinator, Computational Systems Biology of Cancer group, Institut Curie, Paris, France

Acknowledgements

We would like to thank Rudi Balling, the Director of the Luxembourg Centre for Systems Biomedicine for his longstanding and enthusiastic support to the concept of disease maps. He is one of the key people that helped to catalyse the Disease Maps Project.

Most of the published disease maps were developed in collaboration with the Systems Biology Institute, Tokyo, Japan (Mizuno et al., 2012, PMID 22647208; Matsuoka et al., 2013, PMID 24088197; Fujita et al., 2014, PMID 23832570; Kuperstein et al., 2015, PMID 26192618). We would like to underline the role of Prof. Hiroaki Kitano in pioneering the process description representation of signalling networks and initiating first comprehensive disease-relevant extensive reconstructions of signalling pathways (Oda et al., 2005, PMID 16729045; Oda and Kitano, 2006, PMID 16738560; Caron et al., 2010, PMID 21179025).

Funding

The Disease Maps Project is funded in part by IMI eTRIKS n°115446 (eTRIKS, European Translational Information and Knowledge Management Services).