Parkinson’s disease

Parkinson’s Disease Map

Description

Parkinson’s disease (PD) is the second most prevalent neurodegenerative disease in the world. Although many genetic and environmental factors contributing to the risk of PD have been identified, no unique causal mechanism is defined. Information on various aspects of PD pathogenesis is rapidly increasing and needs to be efficiently organized to make this knowledge available for researchers from academia, clinics and pharma industry.

With our partners at the Systems Biology Institute (SBI) in Tokyo, Japan, we have developed the Parkinson’s disease map (PD map) - the first manually curated and high-quality knowledge repository of molecular mechanisms contributing to the complex aetiology of PD. The map compiles information from more than 1000 research articles and public databases into a molecular interaction map.

The PD map displays molecular and biochemical pathways from human brain focused on dopaminergic neurons, including the direct cellular environment (astrocytes, microglia cells) as well as adjacent cellular structures such as blood-brain-barrier and postsynaptic terminals. It comprises cellular processes designated as hallmarks of PD pathogenesis, such as synaptic dysfunction, mitochondrial dysfunction, impaired protein degradation, neuropathobiology of aggregated proteins, or neuroinflammation.

The PD map can be easily explored via an intuitive “Google map” layout also on tablets and smartphones. It offers free access to diverse research-facilitating functionalities: relevant annotation and links to scientific databases, overlay of experimental data, or identification of drug targets and chemical interactions by dedicated interfaces.

Access

http://pdmap.uni.lu

Publications

Development Team

Stephan Gebel Stephan Gebel, PhD
University of Luxembourg, Luxembourg
Researcher, Luxembourg Centre for Systems Biomedicine
Project Manager, the Parkinson's disease map project
Piotr Gawron Piotr Gawron, PhD
University of Luxembourg, Luxembourg
Researcher, Luxembourg Centre for Systems Biomedicine
Marek Ostaszewski Marek Ostaszewski, PhD
University of Luxembourg, Luxembourg
Researcher, Luxembourg Centre for Systems Biomedicine
Rudi Balling Rudi Balling, PhD
University of Luxembourg, Luxembourg
Director, Luxembourg Centre for Systems Biomedicine
Reinhard Schneider Reinhard Schneider, PhD
University of Luxembourg, Luxembourg
Head of Bioinformatics Core, Luxembourg Centre for Systems Biomedicine

Community curation (domain experts: clinicians, biologists)

We encourage the PD community to join forces and support this project by integrating their expertise to continuously refine and expand the knowledge within the PD map. To support that, feedback functions are integrated into the PD map and hands-on workshops with domain experts are regularly organized.

Events

Funding