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Projects

The Disease Maps Community consolidates efforts focused on describing disease mechanisms. We aim to progress together through advancing technological solutions, sharing resources and best practices. New contributors are very welcome: please propose a new disease map or join one of the existing projects. The projects are organised into three categories:

   Disease maps for specific diseases
   Cross-disease projects
   Adverse outcome maps for immunotoxicology

Project progress status:

☆☆☆☆☆ Initiated/funded
★☆☆☆☆ Active development
★★☆☆☆ Available for exploration online
★★★☆☆ Published
★★★★☆ Maintained and improved
★★★★★ Applications demonstrated


Disease maps for specific diseases

The following information cards show projects focused on specific diseases.

Parkinson's disease
★★★★★

Resource: Parkinson's Disease Map
Contact: Marek Ostaszewski, University of Luxembourg, Belvaux, Luxembourg
Publications: PubMed

Cancer
★★★★★

Resource: Atlas of Cancer Signalling Network
Contact: Inna Kuperstein, Institut Curie, Paris, France
Publications: PubMed

Rheumatoid arthritis
★★★★★

Resource: Rheumatoid Arthritis Map
Contact: Anna Niarakis, University of Evry, University of Paris-Saclay, Evry, France
Publications: PubMed

Asthma
★★★☆☆

Resource: AsthmaMap
Contact: Alexander Mazein, University of Luxembourg, Belvaux, Luxembourg
Publications: PubMed

Sarcopenia
★★★☆☆

Resource: Sarcopenia Map
Contact: Matti Hoch, University of Rostock, Rostock, Germany
Publications: PubMed

Cystic fibrosis
★★★☆☆

Resource: CyFi-MAP
Contact: Catarina Pereira, University of Lisbon, Lisbon, Portugal
Publications: PubMed

Heart failure
★★★☆☆

Resource: CardioMap
Contact: Nikolaus Berndt, Charité – Universitätsmedizin Berlin, Germany; Irina Balaur, University of Luxembourg, Belvaux, Luxembourg

Atherosclerosis
★☆★☆★

Resource: Atherosclerosis Map
Contact: Steven Watterson, Ulster University, Derry, Northern Ireland, UK
Publications: PubMed
Model: BioModels

Osteoarthritis of the knee
★★☆☆☆

Resource: KneePainOAMap
Contact: Bernd Seilheimer, Heel GmbH, Germany

Sjogren’s syndrome
★☆☆☆☆

Resource: Sjogren Map
Contact: Sacha E Silva-Saffar, University of Evry, University of Paris-Saclay, France

Diabetic kidney disease
★☆☆☆☆

Resource: Diabetic Kidney Disease Map
Contact: Farnoush Kiyanpour, Isfahan University of Medical Sciences, Isfahan, Iran

Atopic dermatitis
★☆☆☆☆

Resource: Atopic Dermatitis Map
Contact: Marcio Luis Acencio, University of Luxembourg, Belvaux, Luxembourg

Psoriasis
★☆☆☆☆

Resource: Psoriasis Map
Contact: Marcio Luis Acencio, University of Luxembourg, Belvaux, Luxembourg


Cross-disease projects

This section includes projects that focus on shared mechanisms of two or more diseases, interactions between two or more diseases, or broader aspects applicable to many diseases.

Acute inflammation
★★★★★

Resource: Atlas of Inflammation Resolution
Contact: Matti Hoch, University of Rostock, Rostock, Germany
Publications: PubMed

Chronic inflammation
★☆☆☆☆

Resource: SYSCID Map
Diseases: inflammatory bowel disease, rheumatoid arthritis and systemic lupus erythematosus
Contact: Marcio Luis Acencio, University of Luxembourg, Belvaux, Luxembourg

Immune-mediated diseases
★☆☆☆☆

Resource: ImmUniverse Map
Diseases: ulcerative colitis, atopic dermatitis
Contact: Marcio Luis Acencio, University of Luxembourg, Belvaux, Luxembourg


Adverse outcome maps for immunotoxicology

This section includes maps that describe mechanisms of adverse effects of various treatments and are based on the adverse outcome pathway (AOP) concept in toxicology.

CAR T cell treatment
★★★☆☆

Resource: CAR T cell AOP Map
Contact: Alexander Mazein, University of Luxembourg, Belvaux, Luxembourg
Publication: Preprint

Recombinant IL-2 treatment
★☆☆☆☆

Resource: IL-2 AOP Map
Contact: Alexander Mazein, University of Luxembourg, Belvaux, Luxembourg