Projects

The Disease Maps Community consolidates efforts focused on describing disease mechanisms. We aim to progress together through advancing technological solutions, sharing resources and best practices. New contributors are very welcome: please propose a new disease map or join one of the existing projects. The projects are organised into three categories:

   Disease maps for specific diseases
   Cross-disease projects
   Adverse outcome maps for immunotoxicology

Project progress status:

☆☆☆☆☆ Initiated/funded ★☆☆☆☆ Active development ★★☆☆☆ Available for exploration online

★★★☆☆ Published ★★★★☆ Maintained and improved ★★★★★ Applications demonstrated

Disease maps for specific diseases

The following information cards show projects focused on specific diseases.

Parkinson's disease ★★★★★ Resource: Parkinson's Disease Map Contact: Marek Ostaszewski, University of Luxembourg, Belvaux, Luxembourg Publications: PubMed		Cancer ★★★★★ Resource: Atlas of Cancer Signalling Network Contact: Inna Kuperstein, Institut Curie, Paris, France Publications: PubMed
Rheumatoid arthritis ★★★★★ Resource: Rheumatoid Arthritis Map Contact: Anna Niarakis, University of Evry, University of Paris-Saclay, Evry, France Publications: PubMed		Asthma ★★★☆☆ Resource: AsthmaMap Contact: Alexander Mazein, University of Luxembourg, Belvaux, Luxembourg Publications: PubMed
Sarcopenia ★★★☆☆ Resource: Sarcopenia Map Contact: Matti Hoch, University of Rostock, Rostock, Germany Publications: PubMed		Cystic fibrosis ★★★☆☆ Resource: CyFi-MAP Contact: Catarina Pereira, University of Lisbon, Lisbon, Portugal Publications: PubMed
Heart failure ★★★☆☆ Resource: CardioMap Contact: Nikolaus Berndt, Charité – Universitätsmedizin Berlin, Germany; Irina Balaur, University of Luxembourg, Belvaux, Luxembourg		Atherosclerosis ★☆★☆★ Resource: Atherosclerosis Map Contact: Steven Watterson, Ulster University, Derry, Northern Ireland, UK Publications: PubMed Model: BioModels
Osteoarthritis of the knee ★★☆☆☆ Resource: KneePainOAMap Contact: Bernd Seilheimer, Heel GmbH, Germany		Sjogren’s syndrome ★☆☆☆☆ Resource: Sjogren Map Contact: Sacha E Silva-Saffar, University of Evry, University of Paris-Saclay, France
Diabetic kidney disease ★☆☆☆☆ Resource: Diabetic Kidney Disease Map Contact: Farnoush Kiyanpour, Isfahan University of Medical Sciences, Isfahan, Iran		Atopic dermatitis ★☆☆☆☆ Resource: Atopic Dermatitis Map Contact: Marcio Luis Acencio, University of Luxembourg, Belvaux, Luxembourg
Psoriasis ★☆☆☆☆ Resource: Psoriasis Map Contact: Marcio Luis Acencio, University of Luxembourg, Belvaux, Luxembourg

Cross-disease projects

This section includes projects that focus on shared mechanisms of two or more diseases, interactions between two or more diseases, or broader aspects applicable to many diseases.

Acute inflammation ★★★★★ Resource: Atlas of Inflammation Resolution Contact: Matti Hoch, University of Rostock, Rostock, Germany Publications: PubMed		Chronic inflammation ★☆☆☆☆ Resource: SYSCID Map Diseases: inflammatory bowel disease, rheumatoid arthritis and systemic lupus erythematosus Contact: Marcio Luis Acencio, University of Luxembourg, Belvaux, Luxembourg
Immune-mediated diseases ★☆☆☆☆ Resource: ImmUniverse Map Diseases: ulcerative colitis, atopic dermatitis Contact: Marcio Luis Acencio, University of Luxembourg, Belvaux, Luxembourg

Adverse outcome maps for immunotoxicology

This section includes maps that describe mechanisms of adverse effects of various treatments and are based on the adverse outcome pathway (AOP) concept in toxicology.

CAR T cell treatment ★★★☆☆ Resource: CAR T cell AOP Map Contact: Alexander Mazein, University of Luxembourg, Belvaux, Luxembourg Publication: Preprint

Recombinant IL-2 treatment ★☆☆☆☆ Resource: IL-2 AOP Map Contact: Alexander Mazein, University of Luxembourg, Belvaux, Luxembourg