Welcome to the portal for communication, news, guidelines, and other information about the Disease Maps Project, an open community effort to comprehensively represent disease mechanisms for various diseases.
|OPEN PROJECT: The COVID-19 Disease Map is initiated as an open collaboration of many researchers and clinicians around the world. The goal is to develop as quickly as possible a description of host-pathogen interaction mechanisms specific to the SARS-CoV-2 virus to support the fast-track development of efficient treatments. Join the effort!|
COVID-19 Disease Map Mailing List
Contributors - Google Sheets
PUBLICATION: COVID-19 Disease Map, building a computational repository of SARS-CoV-2 virus-host interaction mechanisms. Ostaszewski M, Mazein A, Gillespie ME, Kuperstein I, Niarakis A, Hermjakob H, Pico AR, Willighagen EL, Evelo CT, Hasenauer J, Schreiber F, Dräger A, Demir E, Wolkenhauer O, Furlong LI, Barillot E, Dopazo J, Orta-Resendiz A, Messina F, Valencia A, Funahashi A, Kitano H, Auffray C, Balling R, Schneider R. Sci Data. 2020 May 5;7(1):136. doi: 10.1038/s41597-020-0477-8. PubMed PMID: 32371892
A systems medicine disease map is a high-quality expert community-driven representation of disease mechanisms, a conceptual model of a disease. The detailed layer consists of interconnected signalling, metabolic and gene regulatory pathways stored in standard formats such as SBGN, SBML and BioPAX. The involvement of domain experts (clinicians and biologists) ensures that all the disease hallmarks are covered and relevant knowledge is adequately represented.
In translational medicine projects disease maps are used for advanced ‘omics data interpretation and hypothesis generation, as the basis for mathematical models, for predictive analysis and for building clinical decision support systems. The maps can be used for educational purposes as teaching aids.
The Disease Maps Project is designed as a large-scale community effort. It is a network of groups that work together in order to better understand disease mechanisms. We exchange best practices, share information, develop tools to make it easier for all the involved groups to achieve their goals.