Cystic fibrosis

Cystic Fibrosis Map (CyFi-MAP)

Homepage: https://cysticfibrosismap.github.io
Online access and exploration: WT-CFTR, F508del-CFTR
Development status: First version is complete and published
Disease IDs: DOID:1485, ICD10CM:E84, MESH:D003550, MONDO:0009061
Sustainable support: MINERVA Platform
Construction tools: yEd Graph Editor, CellDesigner
Funding: Fundação para a Ciência e a Tecnologia
How to cite: Pereira et al. Sci Rep. 2021. doi: 10.1038/s41598-021-01618-3. PMID: 34782688.
Contact: Catarina Pereira, University of Lisbon, Portugal, ipereira(at)fc.ul.pt

Description

The Cystic Fibrosis Map project (CyFi-MAP) is an effort focused on high-quality description of cystic fibrosis mechanisms and building a predictive computational model based on this description.

The following approach is used to develop a map of the cystic fibrosis mechanisms. Information from literature is integrated into a large-scale Activity Flow diagram. Particular focus is on various types of mutations of CFTR gene. Information from pathway databases is reused when possible, for example from Reactome and PANTHER, and then contextualised. The network is presented in the Systems Biology Graphical Notation standard (Le Novère, 2009, doi:10.1038/nbt.1558). A community of domain experts is involved to ensure that the disease mechanisms are adequately represented.

The project was initiated by the University of Lisbon and is designed as a joint effort of experts in cystic fibrosis and computational biology research groups. It progresses in the format of a PhD project and is led by Catarina Pereira, a PhD student at the University of Lisbon.

CF-MAP Development Team

	Catarina Pereira, MSc University of Lisbon, Portugal PhD Student, Leader of the CyFi-MAP project
	André Falcão, PhD University of Lisbon, Portugal Assistant Professor, Department of Informatics, Faculty of Sciences Supervisor of the CyFi-MAP PhD project
	Margarida D. Amaral, PhD University of Lisbon, Portugal Professor, Chemistry and Biochemistry Department, Faculty of Sciences Co-supervisor of the CyFi-MAP PhD project
	Alexander Mazein, PhD Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Luxembourg Researcher Co-supervisor of the CyFi-MAP PhD project

References

Pereira C, Mazein A, Farinha CM, Gray MA, Kunzelmann K, Ostaszewski M, Balaur I, Amaral MD, Falcao AO. CyFi-MAP: an interactive pathway-based resource for cystic fibrosis. Sci Rep. 2021 Nov 15;11(1):22223. doi: 10.1038/s41598-021-01618-3. PMID: 34782688.

Funding

This work is supported by the Fundação para a Ciência e a Tecnologia through the PhD Grant ref. PD/BD/131405/2017.