Acute inflammation

Atlas of Inflammation Resolution

Homepage: https://air.bio.informatik.uni-rostock.de
Online access and exploration: https://air.elixir-luxembourg.org
Video tutorials: https://air.bio.informatik.uni-rostock.de/using-the-air/tutorial-videos
Development status: First version is complete and published, applications demonstrated
Sustainable support: University of Rostock, MINERVA Platform
Construction tool: CellDesigner
Funding: The initial version has received support from Heel, GmbH, Baden-Baden
How to cite: Serhan, et al. Mol Aspects Med. 2020. doi: 10.1016/j.mam.2020.100894. PMID: 32893032
Contact: Matti Hoch, University of Rostock, Rostock, Germany, matti.hoch(at)uni-rostock.de


The Atlas of Inflammation Resolution (AIR) provides a comprehensive resource focused on acute inflammation, a nonlinear spatio-temporal process for the removal of invading pathogens and the repair of damaged tissues. It covers damage-, and pathogen-associated molecular patterns (DAMPs and PAMPs), relevant signaling events, protein-protein interactions and gene regulatory mechanisms underlying acute inflammatory clinical phenotypes.


Serhan CN, Gupta SK, Perretti M, Godson C, Brennan E, Li Y, Soehnlein O, Shimizu T, Werz O, Chiurchiù V, Azzi A, Dubourdeau M, Gupta SS, Schopohl P, Hoch M, Gjorgevikj D, Khan FM, Brauer D, Tripathi A, Cesnulevicius K, Lescheid D, Schultz M, Särndahl E, Repsilber D, Kruse R, Sala A, Haeggström JZ, Levy BD, Filep JG, Wolkenhauer O. The Atlas of Inflammation Resolution (AIR). Mol Aspects Med. 2020 Aug;74:100894. doi: 10.1016/j.mam.2020.100894. PMID: 32893032.

Hoch M, Smita S, Cesnulevicius K, Lescheid D, Schultz M, Wolkenhauer O, Gupta S. Network- and enrichment-based inference of phenotypes and targets from large-scale disease maps. NPJ Syst Biol Appl. 2022 Apr 26;8(1):13. doi: 10.1038/s41540-022-00222-z. PMID: 35473910.

Hoch M, Smita S, Cesnulevicius K, Schultz M, Lescheid D, Wolkenhauer O, Gupta S. Network analyses reveal new insights into the effect of multicomponent Tr14 compared to single-component diclofenac in an acute inflammation model. J Inflamm (Lond). 2023 Mar 27;20(1):12. doi: 10.1186/s12950-023-00335-0. PMID: 36973809.

Hoch M, Rauthe J, Cesnulevicius K, Schultz M, Lescheid D, Wolkenhauer O, Chiurchiù V, Gupta S. Cell-Type-Specific Gene Regulatory Networks of Pro-Inflammatory and Pro-Resolving Lipid Mediator Biosynthesis in the Immune System. Int J Mol Sci. 2023 Feb 22;24(5):4342. doi: 10.3390/ijms24054342. PMID: 36901771.