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Sevilla

The 2019 community meeting is hosted by the Clinical Bioinformatics Area, FPS, Hospital Virgen del Rocío.

We are glad to announce the 4th Disease Maps Community Meeting (DMCM2019) that will take place 2nd - 4th October in Hospital Virgen del Rocio, Sevilla, Spain.

The event is held on yearly basis and presents advances in our knowledge on the molecular mechanisms of diseases, in mathematical modelling for understanding their progression and in developing software for supporting maps and carrying out different types of analyses. The meeting includes not only presentations and posters but also software demos and discussions on hot topics in systems medicine. Please see, for example, the outcome of the Luxembourg meeting discussions recently published in Briefings in Bioinformatics.

The booklet is available here

Photos from the meeting are available at #DMCM2019 Twitter Pictures


Key dates

Abstract submission deadline: 21st July 2019 (extended)
Decision on abstract selection: 15th August 2019
Registration deadline: 15th September 2019
DMCM2019: 2nd - 4th October 2019

Invited speakers

Inge Jonassen Inge Jonassen, PhD, University of Bergen. Norway

Dr. Jonassen is a Full Professor at the department of Informatics at the University of Bergen. He is also the head of the Computational Biology Unit at the same university and the head of the Norwegian Node of ELIXIR, the European infrastructure for bioinformatics. His research focuses on development and advanced application of methods for analysis of omics data and discovery of patterns in molecular biological data. He is associated with the CCBIO Centre for Cancer Biomarkers in Bergen and also with the NeuroSysMed research centre for clinical treatment in neurodegenerative diseases. More information: Jonassen Group.

Julio Saez-Rodriguez Julio Saez-Rodriguez, PhD, RWTH-Aachen University, Germany

Julio Saez-Rodriguez is Professor of Medical Bioinformatics and Data Analysis at the Faculty of Medicine of Heidelberg University. Julio is a member of the Disease Maps team and participates in the development of the Multiple Sclerosis Map. Julio's research interests are in computational methods and tools for studying information transfer within signalling networks, and applications to disease-related questions, with a focus on cancer and fibrosis. More information can be found at http://saezlab.org.

Jonathan Karr Jonathan Karr, PhD, Icahn School of Medicine at Mount Sinai, USA

Jonathan Karr is a Fellow at the Icahn School of Medicine at Mount Sinai in New York. The goal of Jonathan's research group is to develop mechanistic whole-cell computational models that predict the behavior of individual cells by representing all of the biochemical activity in cells. Jonathan earned his PhD in Biophysics and his MS in Medicine from Stanford University and his SB in Physics and SB in Brain & Cognitive Sciences from MIT. See his research group's website for more information: https://www.karrlab.org.

Sampsa Hautaniemi Sampsa Hautaniemi, PhD, University of Helsinki, Finland

Sampsa Hautaniemi is a Professor of Systems Biology and the Director of Systems Oncology research program at the Faculty of Medicine of the University of Helsinki. His research focuses on developing and applying machine learning methods to understanding and overcoming drug resistance in cancers. More information can be found at the Hautaniemi lab.

Programme

Wednesday 2nd October

09:00 Disease Maps Members/Coordinators Meeting

10:30 Coffee Break

Session 1: Using existing data to create disease maps

11:00 Welcome
Joaquin Dopazo, Clinical Bioinformatics Area, FPS, Sevilla, Spain
11:10 Opening Key Lecture 1
Analysis of multi-omics data to improve the understanding of Parkinson’s disease

Inge Jonassen, University of Bergen, Norway
12:10 Short talks
Towards automatic assembly and management of evolving disease models: modularisation, merging, layout, comparison and versioning

Alexander Mazein, University of Luxembourg, Luxembourg

Common disease mechanisms at play? A modelling challenge
Rudi Balling, University of Luxembourg, LCSB, Luxembourg

Disease map for aHUS – molecular mechanisms and hypotheses
Tatiana Serebriyskaya, RacursBioMed Ltd., Russia

A disease map and a database for cystic fibrosis
Catarina Pereira, University of Lisboa Faculty of Sciences, BioISI – Biosystems and Integrative Science Institute, Lisboa, Portugal
14:00 Lunch and Poster viewing

Session 2: Computational models

15:30 Key Lecture 2 Toward whole-cell computational models for precision medicine
Jonathan Karr, Icahn School of Medicine at Mount Sinai, New York, USA
16:30 Short talks
A multiscale modelling platform to simulate drug synergies in different cell population architectures.

Miguel Ponce de Leon, Barcelona Supercomputing Center, Barcelona, Spain

Executable Disease Maps – Addressing the challenges of large scale dynamical modelling
Anna Niarakis, GenHotel, University of Evry, Paris-Saclay, France

Generation of process diagrams for computational modelling: lessons from the classroom
Tom C. Freeman, The Roslin Institute and Royal (Dick) School of Veterinary Studies, The University of Edinburgh, Edinburgh, UK

Thursday 3rd October

Session 3: Multi-view data integration

9:00 Key Lecture:
Logic modelling to integrate disease maps and various omics data

Julio Saez-Rodriguez, RWTH-Aachen University Hospital, Aachen, Germany
10:00 Highlighted talk
Elixir Sponsor talk

10:30 Coffee break and poster viewing

11:00 Selected short talks
Atlas of Cancer Signaling Network: a resource of multi-scale biological maps to study disease mechanisms
Luis Cristobal Monraz Gomez, Institut Curie, France

Interactive visualization of phenotypic and genotypic information in disease maps for identification of mechanistic biomarkers
Sascha Herzinger, University of Luxembourg, Luxembourg Centre for Systems Biomedicine, Luxembourg

Reactome Pathway Analysis and Visualization
Henning Hermjakob, EMBL-EBI, United Kingdom
12:30 Poster session
Flash presentations

13:30 Lunch and poster viewing

Session 4: Discussions

15:00 Introduction
15:30 Discussion topics
Four discussion sessions (Topics to be determined)
17:30 Presentation preparation and final discussion
18:30 Results presentation
20:30 Gala Dinner

Friday 4th October

Session 5: Clinical application of disease maps

09:00 Key Lecture 4
Computational approaches to tackle chemoresistance in high-grade serous ovarian cancer

Sampsa Hautaniemi, Faculty of Medicine, University of Helsinki, Finland
10:00 The DisGeNET platform’s 10 anniversary
Developing a knowledge base for disease genomics

Janet Piñero, GRIB (IMIM-UPF), Spain

10:30 Coffee break

11:00 Short talks
Machine learning and mechanistic models for drug repositioning in rare diseases

Marina Esteban-Medina, Clinical Bioinformatics Area, FPS, Sevilla, Spain

Connecting metabolic biomarkers with biological pathways and clinical data to enable omics data interpretation
Denise N. Slenter, Maastricht University, Netherlands

Conciliation of medicine systems disease maps and other molecular interaction networks using logical properties of ontology
Vincent Henry, Inria/ICM, Paris, France

Different layout aware formats in systems biology used by Minerva platform
Piotr Gawron, University of Luxembourg, Luxembourg

13:00 Poster viewing

13:30 Lunch

Hands-on session

Tutorials of the following tools and resources

14:30 BiNoM, ACSN
14:30 MINERVA
15:30 Hipathia

NaviCell tutorial materials (zip)

(Depending on computers and rooms available, will be distributed in one or two parallel hands-on sessions)

17:00h Meeting closure

Abstract submission

Please submit an abstract (up to 400 words) via the submission link for an oral presentation and/or a poster.

Abstract submission deadline: 21st July 2019 (extended).

Registration

The registration is free but mandatory. Please fill in the registration form.

Registration deadline: 15th September 2019.

Location

Edificio de Gobierno, Hospital Universitario Virgen del Rocío
Avenida Manuel Siurot s/n, 41013 Seville, Spain


Accommodation

Recommended hotels:

AC Hotel Ciudad de Sevilla, a Marriott Lifestyle Hotel
AV Manuel Siurot 25, 41013 Seville, Spain
Tel. +34 954 230 505

Silken Al-Andalus Palace
Avenida de la Palmera s/n, esq. C/ Paraná, 41012 Seville, Spain
Tel. +34 954 230 600

EXE Sevilla Palmera
Cardenal Ilundain, 28, 41013 Seville, Spain
Tel. +34 932 087 108
(5 minutes walk from the event)

Melia Sevilla
Dr. Pedro de Castro, 1, 41004 Seville, Spain
Tel. +34 912 764 747

Organisers

Local organisers

Clinical Bioinformatics Area Group
Joaquin Dopazo
Rubén García Serrano
Maria Peña Chilet

Disease Maps Project Coordinators

Alexander Mazein
Marek Ostaszewski
Inna Kuperstein
Anna Niarakis
Andrei Zinovyev
Reinhard Schneider
Emmanuel Barillot
Rudi Balling
Charles Auffray

Contact

If you have any questions, please contact Inmaculada Guillén at the technical secretariat of the CBA group and the Disease Maps Organisers.

Co-organizers

inb iscii

The Spanish National Bioinformatics Institute (INB) is the ISCIII Bioinformatics platform. Its Coordination Node is supported by grant PT17/0009/0001, of the Acción Estratégica en Salud 2013-2016 of the Programa Estatal de Investigación Orientada a los Retos de la Sociedad, funded by the Instituto de Salud Carlos III (ISCIII) and European Regional Development Fund (ERDF)