Asthma

AsthmaMap

AsthmaMap is a community-driven project initiated as a part of U-BIOPRED (Unbiased Biomarkers for the Prediction of Respiratory Disease Outcomes) data analysis and integration platform and then continued within eTRIKS (European Translational Information and Knowledge Management Services).

The objectives are:

  1. Develop a pathway-based network reconstruction of the asthma mechanisms.
  2. Map fingerprints (one type of 'omics) and handprints data (several types of 'omics) to the network.
  3. Perform network-based analysis, interpretation and hypothesis generation.
  4. Propose disease endotypes.

AsthmaMap is constructed based on literature mining, with systematic review by domain experts. It is a consensus view on asthma mechanisms that consists of three layers of granularity:

The high-level view includes 22 cell types and is connected to the underlying pathways. It can be used for data interpretation on systems level while keeping the focus on the involvement of different cell types in asthma pathogenesis. U-BIOPRED data mapping and interpretation are ongoing. After sufficient validation, proposed endotypes can be used for redefining disease subtypes and fine-tuning of diagnosis and treatment.

AsthmaMap is being developed in close collaboration with the LCSB Parkinson's disease map team. MINERVA platform is employed for online visualisation.

Press release

AsthmaMap Editoral Panel

Peter Sterk Peter Sterk, MD
University of Amsterdam, Netherlands
Professor of the Pathophysiology and Phenotyping of Asthma and COPD at the Faculty of Medicine
Coordinator of the IMI U-BIOPRED project
Fan Chung Fan Chung, MD
Imperial College London, UK
Professor of Respiratory Medicine and Head of Experimental Studies Medicine at the National Heart & Lung Institute,
Consultant Physician at the Royal Brompton & Harefield NHS Trust, London
Richard Knowles Richard Knowles, PhD
Knowles Consulting, UK
Scientific Drug Discovery Consultant at the Stevenage Bioscience Catalyst
Craig Wheelock Craig Wheelock, PhD
Karolinska Institutet, Sweden
Head of the Integrative Molecular Phenotyping laboratory,
Division of Physiological Chemistry II, Department of Medical Biochemistry and Biophysics
Sven-Erik Dahlen Sven-Erik Dahlen, MD, PhD
Karolinska Institutet, Sweden
Professor in Experimental Asthma and Allergy Research
Ian Adcock Ian Adcock, PhD
Imperial College London, UK
Professor of Respiratory Cell & Molecular Biology,
Head of the Molecular Cell Biology Group at the National Heart & Lung Institute
Anke-Hilse Maitland-van der Zee Anke-Hilse Maitland-van der Zee, PhD
Academic Medical Center, Amsterdam, Netherlands
Professor Precision Medicine in Respiratory Disease,
President of the Federation of Innovative Drug Research in the Netherlands, Coordinator of the ERANET SysPharmPediA project
Peter Openshaw Peter Openshaw, MD
Imperial College London, UK
Professor of Experimental Medicine, Honorary Physician in the Department of Respiratory Medicine,
President of the British Society for Immunology
Ratko Djukanovic Ratko Djukanovic, MD, DM, FRCP
University of Southampton, UK
Professor of Medicine, Director of the Southampton NIHR Respiratory Biomedical Research Unit,
Director of the NIHR Southampton Centre for Biomedical Research
Graham Roberts Graham Roberts, DM, MRCPCH, MA, MSc
University of Southampton, UK
Professor and Honorary Consultant Paediatrician in Paediatric Allergy and Respiratory Medicine

AsthmaMap Development Team

Alexander Mazein Alexander Mazein, PhD
European Institute for Systems Biology and Medicine, France
Senior Researcher
Diane Lefaudeux Diane Lefaudeux, MSc
European Institute for Systems Biology and Medicine, France
Research Engineer
Bertrand De Meulder Bertrand De Meulder, PhD
European Institute for Systems Biology and Medicine, France
Researcher
Irina Balaur Irina Balaur, PhD
European Institute for Systems Biology and Medicine, France
Researcher
Charles Auffray Charles Auffray, PhD
European Institute for Systems Biology and Medicine, France
Research Director at CNRS, Founding Director of the EISBM

Funding