Acute kidney injury

The regulatory network of systemic and renal hemodynamics

Description

AKIPREV aims at developing a computerized clinical decision support system (CDSS) that will help physicians to stratify patients, and optimize antihypertensive and analgesic drug treatments. AKIPREV-CDSS works on a conceptually innovative approach that evaluates the individual’s functional phenotype, based on a multiparametric computation of selected analytical parameters and personal data. Objectives of this project are:

  1. To develop and preclinically validate a disease and pharmacological model of interactions among the key regulatory mechanisms and molecular players of systemic and renal hemodynamics, and the associated markers (descriptors) that describe the status of the hemodynamic network, on which drugs exert their effects.
  2. To develop a computerized mathematical model (algorithm) that, when fed with the values of the descriptors of each individual patient will:
    • Describe the status of their hemodynamic network; and based on it,
    • Predict the effect of drugs and drug combinations on blood pressure, and renal function.
  3. To carry out clinical validation and adjustment of the computerized model with data from patients subject to drug treatments.

The project will:

  1. Provide personalized treatment for hypertension and pain based on disease mechanisms knowledge.
  2. Integrate patient’s multidimensional and longitudinal data.
  3. Use proteomics and pharmacogenomics, systems biomedicine, network analysis and computational modelling.
  4. Perform pre-clinical and clinical studies.
  5. Address sex and gender differences.
  6. Involve patient associations
  7. Consider regulatory aspects.
  8. Develop a dissemination and commercialisation plan.
  9. Focus on a complex disease, hypertension, with high prevalence and economic impact.

Development Team

Francisco J. López-Hernández Francisco J. López-Hernández, PhD
Salamanca Biomedical Research Institute & University of Salamanca, Spain
Group Leader, Senior Researcher and Assistant Professor
Carlos Martínez-Salgado Carlos Martínez-Salgado, PhD
Salamanca Biomedical Research Institute & University of Salamanca, Spain
Head of Research Group, Senior Research Scientist and Associate Professor
Ana I. Morales Martín Ana I. Morales Martín, PhD
University of Salamanca & Salamanca Biomedical Research Institute, Spain
Head Professor
Bertrand De Meulder Bertrand De Meulder, PhD
European Institute for Systems Biology and Medicine, France
Researcher

Editorial Panel (Domain Experts)

Armin Kurtz Armin Kurtz, MD
Universität Regensburg, Germany
Chair of Physiology, Institut für Physiologie
José D. Martín Guerrero José D. Martín Guerrero, PhD
University of Valencia, Spain
Associate Professor, Intelligent Data Analysis Laboratory
Jolanta Malyszko Jolanta Malyszko, MD, PhD
Medical University of Bialystok, Poland
Professor, 2nd Department of Nephrology and Hypertension
Alberto Ortiz Alberto Ortiz, MD, PhD
Fundacion Jimenez Diaz & University Autonoma of Madrid, Spain
Chief of Nephrology, Professor of Medicine
Patrick C. D'Haese Patrick C. D'Haese, PhD
University of Antwerp, Belgium
Head Laboratory of Pathophysiology, Department Biomedical Sciences
Rhian M Touyz Rhian M. Touyz, MBBCh, PhD, FRCP, FRSE
University of Glasgow, UK
Director of Research Institute, Institute of Cardiovascular and Medical Sciences
British Heart Foundation Chair of Cardiovascular Medicine