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Asthma

AsthmaMap

Homepage: https://asthma-map.org
Online access and exploration: https://asthma.uni.lu
Video tutorials: https://asthma-map.org/tutorials
Development status: First version is complete and published
Disease IDs: DOID:2841, MESH:D001249, MONDO:0004979, ICD10CM:J45
Sustainable support: MINERVA Platform
Construction tools: yEd Graph Editor, CellDesigner
Funding: IMI U-BIOPRED n°115010, IMI eTRIKS n°115446
How to cite: Mazein, et al. J Allergy Clin Immunol. 2020. PMID: 33309742
Contact: Alexander Mazein, University of Luxembourg, a.mazein(at)gmail.com

AsthmaMap (http://asthma-map.org) is a community-driven project initiated as a part of U-BIOPRED (Unbiased Biomarkers for the Prediction of Respiratory Disease Outcomes) data analysis and integration platform and then continued within eTRIKS (European Translational Information and Knowledge Management Services).

The objectives are:

  1. Develop a pathway-based network reconstruction of the asthma mechanisms.
  2. Map fingerprints (one type of 'omics) and handprints data (several types of 'omics) to the network.
  3. Perform network-based analysis, interpretation and hypothesis generation.
  4. Propose disease endotypes.

AsthmaMap is constructed based on literature mining, with systematic review by domain experts. It is a consensus view on asthma mechanisms that consists of three interconnected layers of granularity:

layers

The high-level view includes 22 cell types and is connected to the underlying pathways. It can be used for data interpretation on systems level while keeping the focus on the involvement of different cell types in asthma pathogenesis. U-BIOPRED data mapping and interpretation are ongoing. After sufficient validation, proposed endotypes can be used for redefining disease subtypes and fine-tuning of diagnosis and treatment.

AsthmaMap is being developed in close collaboration with the LCSB MINERVA team.

Publications

Mazein A, Ivanova O, Balaur I, Ostaszewski M, Berzhitskaya V, Serebriyskaya T, Ligon T, Hasenauer J, De Meulder B, Overall RW, Roy L, Knowles RG, Wheelock CE, Dahlen SE, Chung KF, Adcock IM, Roberts G, Djukanovic R, Pellet J, Gawron P, Balling R, Maitland-van der Zee AH, Schneider R, Sterk PJ, Auffray C; U-BIOPRED Study Group and the eTRIKS Consortium. AsthmaMap: an interactive knowledge repository for mechanisms of asthma. J Allergy Clin Immunol. 2020 Dec 9:S0091-6749(20)31707-3. doi: 10.1016/j.jaci.2020.11.032. Epub ahead of print. PMID: 33309742.

Mazein A, Knowles RG, Adcock I, Chung KF, Wheelock CE, Maitland-van der Zee AH, Sterk PJ, Auffray C; AsthmaMap Project Team. AsthmaMap: An expert-driven computational representation of disease mechanisms. Clin Exp Allergy. 2018 Aug;48(8):916-918. doi: 10.1111/cea.13211. PubMed PMID: 30133857.

AsthmaMap Editorial Panel

Peter Sterk Peter Sterk, MD
University of Amsterdam, Netherlands
Professor of the Pathophysiology and Phenotyping of Asthma and COPD at the Faculty of Medicine
Coordinator of the IMI U-BIOPRED project
Fan Chung Fan Chung, MD
Imperial College London, UK
Professor of Respiratory Medicine and Head of Experimental Studies Medicine at the National Heart & Lung Institute,
Consultant Physician at the Royal Brompton & Harefield NHS Trust, London
Richard Knowles Richard Knowles, PhD
Knowles Consulting, UK
Scientific Drug Discovery Consultant at the Stevenage Bioscience Catalyst
Craig Wheelock Craig Wheelock, PhD
Karolinska Institutet, Sweden
Head of the Integrative Molecular Phenotyping laboratory,
Division of Physiological Chemistry II, Department of Medical Biochemistry and Biophysics
Sven-Erik Dahlen Sven-Erik Dahlen, MD, PhD
Karolinska Institutet, Sweden
Professor in Experimental Asthma and Allergy Research
Ian Adcock Ian Adcock, PhD
Imperial College London, UK
Professor of Respiratory Cell & Molecular Biology,
Head of the Molecular Cell Biology Group at the National Heart & Lung Institute
Anke-Hilse Maitland-van der Zee Anke-Hilse Maitland-van der Zee, PhD
Academic Medical Center, Amsterdam, Netherlands
Professor Precision Medicine in Respiratory Disease,
President of the Federation of Innovative Drug Research in the Netherlands, Coordinator of the ERANET SysPharmPediA project
Ratko Djukanovic Ratko Djukanovic, MD, DM, FRCP
University of Southampton, UK
Professor of Medicine, Director of the Southampton NIHR Respiratory Biomedical Research Unit,
Director of the NIHR Southampton Centre for Biomedical Research
Graham Roberts Graham Roberts, DM, FRCPCH, MA, MSc
University of Southampton, UK
Professor and Honorary Consultant Paediatrician in Paediatric Allergy and Respiratory Medicine

AsthmaMap Development Team

Alexander Mazein Alexander Mazein, PhD
European Institute for Systems Biology and Medicine, France
Researcher
Irina Balaur Irina Balaur, PhD
European Institute for Systems Biology and Medicine, France
Researcher
Olga Ivanova Olga Ivanova, MSc
European Institute for Systems Biology and Medicine, France
Research Intern
Ludovic Roy Ludovic Roy, MSc
European Institute for Systems Biology and Medicine, France
Researcher
Bertrand De Meulder Bertrand De Meulder, PhD
European Institute for Systems Biology and Medicine, France
Researcher
Tatiana Serebriyskaya Tatiana Serebriyskaya, PhD
Moscow Institute of Physics and Technology, Russia
Head of the Laboratory for Translational Research and Personalized Medicine
Valeriya Berzhitskaya Valeriya Berzhitskaya, PhD
Moscow Institute of Physics and Technology, Russia
Researcher
Rupert Overall Rupert Overall, PhD
German Center for Neurodegenerative Diseases (DZNE), Dresden, Germany
Platform Leader, Cognitive Resilience Map
Johann Pellet Johann Pellet, MSc
European Institute for Systems Biology and Medicine, France
Researcher
Charles Auffray Charles Auffray, PhD
European Institute for Systems Biology and Medicine, France
Research Director at CNRS, Founding Director of the EISBM

Modelling

Jan Hasenauer Jan Hasenauer, PhD
Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany
Group Leader, Institute of Computational Biology
Thomas Ligon Thomas Ligon, PhD
Ludwig Maximilian University of Munich, Munich, Germany
Guest Scientist, Faculty of Physics and Center for NanoScience

AsthmaMap support in MINERVA

Piotr Gawron Piotr Gawron, PhD
University of Luxembourg, Luxembourg
Researcher, Luxembourg Centre for Systems Biomedicine
Marek Ostaszewski Marek Ostaszewski, PhD
University of Luxembourg, Luxembourg
Researcher, Luxembourg Centre for Systems Biomedicine
Reinhard Schneider Reinhard Schneider, PhD
University of Luxembourg, Luxembourg
Head of Bioinformatics Core, Luxembourg Centre for Systems Biomedicine
Rudi Balling Rudi Balling, PhD
University of Luxembourg, Luxembourg
Director, Luxembourg Centre for Systems Biomedicine

Funding

The AsthmaMap project is funded in part by the Innovative Medicines Initiative (IMI) funded by the European Union and the European Federation of Pharmaceutical Industry Associations through U-BIOPRED (Unbiased Biomarkers for the Prediction of Respiratory Disease Outcomes, n°115010) and eTRIKS (European Translational Information and Knowledge Management Services, IMI n°115446), the French National Center for Scientific Research (CNRS), the European Institute for Systems Biology and Medicine and the Luxembourg Center for Systems Biomedicine.