Acute kidney injury

The regulatory network of systemic and renal hemodynamics


AKIPREV aims at developing a computerized clinical decision support system (CDSS) that will help physicians to stratify patients, and optimize antihypertensive and analgesic drug treatments. AKIPREV-CDSS works on a conceptually innovative approach that evaluates the individual’s functional phenotype, based on a multiparametric computation of selected analytical parameters and personal data. Objectives of this project are:

  1. To develop and preclinically validate a disease and pharmacological model of interactions among the key regulatory mechanisms and molecular players of systemic and renal hemodynamics, and the associated markers (descriptors) that describe the status of the hemodynamic network, on which drugs exert their effects.
  2. To develop a computerized mathematical model (algorithm) that, when fed with the values of the descriptors of each individual patient will:
    • Describe the status of their hemodynamic network; and based on it,
    • Predict the effect of drugs and drug combinations on blood pressure, and renal function.
  3. To carry out clinical validation and adjustment of the computerized model with data from patients subject to drug treatments. </ol>

    The project will:

    1. Provide personalized treatment for hypertension and pain based on disease mechanisms knowledge.
    2. Integrate patient’s multidimensional and longitudinal data.
    3. Use proteomics and pharmacogenomics, systems biomedicine, network analysis and computational modelling.
    4. Perform pre-clinical and clinical studies.
    5. Address sex and gender differences.
    6. Involve patient associations
    7. Consider regulatory aspects.
    8. Develop a dissemination and commercialisation plan.
    9. Focus on a complex disease, hypertension, with high prevalence and economic impact.

    Development Team

    Francisco J. López-Hernández Francisco J. López-Hernández, PhD
    Salamanca Biomedical Research Institute & University of Salamanca, Spain
    Group Leader, Senior Researcher and Assistant Professor
    Carlos Martínez-Salgado Carlos Martínez-Salgado, PhD
    Salamanca Biomedical Research Institute & University of Salamanca, Spain
    Head of Research Group, Senior Research Scientist and Associate Professor
    Ana I. Morales Martín Ana I. Morales Martín, PhD
    University of Salamanca & Salamanca Biomedical Research Institute, Spain
    Head Professor
    Anita T. Layton Anita T. Layton, PhD
    Duke University, Durham, North Carolina, USA
    Professor of Mathematics, Medicine & Biomedical Engineering at the Duke University, Durham, North Carolina, USA
    Professor of Applied Mathematics at the University of Waterloo, Waterloo, Canada
    Bertrand De Meulder Bertrand De Meulder, PhD
    European Institute for Systems Biology and Medicine, France

    Editorial Panel (Domain Experts)

    Armin Kurtz Armin Kurtz, MD
    Universität Regensburg, Germany
    Chair of Physiology, Institut für Physiologie
    José D. Martín Guerrero José D. Martín Guerrero, PhD
    University of Valencia, Spain
    Associate Professor, Intelligent Data Analysis Laboratory
    Jolanta Malyszko Jolanta Malyszko, MD, PhD
    Medical University of Bialystok, Poland
    Professor, 2nd Department of Nephrology and Hypertension
    Alberto Ortiz Alberto Ortiz, MD, PhD
    Fundacion Jimenez Diaz & University Autonoma of Madrid, Spain
    Chief of Nephrology, Professor of Medicine
    Patrick C. D'Haese Patrick C. D'Haese, PhD
    University of Antwerp, Belgium
    Head Laboratory of Pathophysiology, Department Biomedical Sciences
    Rhian M Touyz Rhian M. Touyz, MBBCh, PhD, FRCP, FRSE
    University of Glasgow, UK
    Director of Research Institute, Institute of Cardiovascular and Medical Sciences
    British Heart Foundation Chair of Cardiovascular Medicine