Acute kidney injury

The regulatory network of systemic and renal hemodynamics

Description

AKIPREV aims at developing a computerized clinical decision support system (CDSS) that will help physicians to stratify patients, and optimize antihypertensive and analgesic drug treatments. AKIPREV-CDSS works on a conceptually innovative approach that evaluates the individual’s functional phenotype, based on a multiparametric computation of selected analytical parameters and personal data. Objectives of this project are:

1. To develop and preclinically validate a disease and pharmacological model of interactions among the key regulatory mechanisms and molecular players of systemic and renal hemodynamics, and the associated markers (descriptors) that describe the status of the hemodynamic network, on which drugs exert their effects.
2. To develop a computerized mathematical model (algorithm) that, when fed with the values of the descriptors of each individual patient will:
   • Describe the status of their hemodynamic network; and based on it,
   • Predict the effect of drugs and drug combinations on blood pressure, and renal function.
3. To carry out clinical validation and adjustment of the computerized model with data from patients subject to drug treatments.

The project will:

1. Provide personalized treatment for hypertension and pain based on disease mechanisms knowledge.
2. Integrate patient’s multidimensional and longitudinal data.
3. Use proteomics and pharmacogenomics, systems biomedicine, network analysis and computational modelling.
4. Perform pre-clinical and clinical studies.
5. Address sex and gender differences.
6. Involve patient associations.
7. Consider regulatory aspects.
8. Develop a dissemination and commercialisation plan.
9. Focus on a complex disease, hypertension, with high prevalence and economic impact.

Development Team

	Francisco J. López-Hernández, PhD Salamanca Biomedical Research Institute & University of Salamanca, Spain Group Leader, Senior Researcher and Assistant Professor
	Carlos Martínez-Salgado, PhD Salamanca Biomedical Research Institute & University of Salamanca, Spain Head of Research Group, Senior Research Scientist and Associate Professor
	Ana I. Morales Martín, PhD University of Salamanca & Salamanca Biomedical Research Institute, Spain Head Professor
	Anita T. Layton, PhD Duke University, Durham, North Carolina, USA Professor of Mathematics, Medicine & Biomedical Engineering at the Duke University, Durham, North Carolina, USA Professor of Applied Mathematics at the University of Waterloo, Waterloo, Canada
	Bertrand De Meulder, PhD European Institute for Systems Biology and Medicine, France Researcher

Editorial Panel (Domain Experts)

	Armin Kurtz, MD Universität Regensburg, Germany Chair of Physiology, Institut für Physiologie
	José D. Martín Guerrero, PhD University of Valencia, Spain Associate Professor, Intelligent Data Analysis Laboratory
	Jolanta Malyszko, MD, PhD Medical University of Bialystok, Poland Professor, 2nd Department of Nephrology and Hypertension
	Alberto Ortiz, MD, PhD Fundacion Jimenez Diaz & University Autonoma of Madrid, Spain Chief of Nephrology, Professor of Medicine
	Patrick C. D'Haese, PhD University of Antwerp, Belgium Head Laboratory of Pathophysiology, Department Biomedical Sciences
	Rhian M. Touyz, MBBCh, PhD, FRCP, FRSE University of Glasgow, UK Director of Research Institute, Institute of Cardiovascular and Medical Sciences British Heart Foundation Chair of Cardiovascular Medicine